Liver Disease Topic Guide

Liver disease is a term used for many health problems that prevent the liver from working properly. The liver is the largest organ inside your body. It helps digest food, store energy, and remove harmful substances from the blood. It also processes and delivers nutrients your body needs to work properly. When the liver is damaged, it cannot do these jobs well. There are many types of liver disease. Some are caused by viruses, such as hepatitis A, B, and C. Others are linked to alcohol, drugs, or toxins and can lead to conditions like fatty liver disease or cirrhosis, which causes scarring of the liver. Liver disease can also be caused by cancer or inherited conditions.

American Indian/Alaska Native

In 2022, American Indians/Alaska Natives (AI/AN) were nearly five times more likely than the U.S. population overall to die from chronic liver disease and cirrhosis. In 2018, AI/AN adults were diagnosed with liver disease 47% more often than adults in the U.S. overall.

For additional data on liver disease and American Indians/Alaska Natives, please visit our Population Profiles.

Asian American

In 2022, Asian Americans were 70% less likely than the total U.S. population overall to die from chronic liver disease and cirrhosis. In 2018, Asian American adults were diagnosed with liver disease 6% more often than adults overall in the U.S.

For additional data on liver disease and Asian Americans, please visit our Population Profiles.

Black/African American

In 2022, Black/African Americans were 36% less likely than the U.S. population overall to die from chronic liver disease and cirrhosis. In 2018, Black/African American adults were diagnosed with liver disease 35% less often than adults overall in the U.S.

For additional data on liver disease and Black or African Americans, please visit our Population Profiles.

Hispanic/Latino

In 2022, Hispanics/Latinos were 23% more likely than the U.S. population overall to die from chronic liver disease and cirrhosis. In 2018, Hispanic/Latino adults were diagnosed with liver disease 59% more often than adults overall in the U.S. In 2018, Mexican American adults were diagnosed with liver disease twice as often as the U.S. population overall.

For additional data on liver disease and Hispanic Americans, please visit our Population Profiles.

Native Hawaiian/Pacific Islander

In 2022, Native Hawaiians/Pacific Islanders (NHPI) were 46% less likely than the U.S. population overall to die from chronic liver disease and cirrhosis.

For additional data on liver disease and Native Hawaiians/Pacific Islanders, please visit our Population Profiles.


Date Last Reviewed: February 2026