Cancer and American Indians/Alaska Natives

Cancer is a disease where some cells in the body grow out of control and can spread to other parts of the body. Cancer can start almost anywhere because the body is made up of trillions of cells. Normally, cells grow, divide, and die in an orderly way. When old or damaged cells die, new cells replace them. Sometimes this process does not work properly, and abnormal or damaged cells keep growing when they should not. These cells may form tumors, which are lumps of tissue. Some tumors can be cancerous and can spread to or invade nearby tissues. Many cancers form solid tumors, but blood cancers, like leukemia, usually do not.

You can lower your risk of developing many common cancers by making healthy lifestyle choices. Screening tests can find some cancers early, when they are easier to treat. Vaccines can also help prevent certain types of cancer.

Occurrence

Cancer among adults ages 18 and over, age-adjusted percentage, 2024
CancerAI/ANTotal PopulationRatio (AI/AN / Total)
All Sites9.210.30.89
Breast1.91.81.06
Cervical (Females)0.90.71.29
Prostate (Males)Not Reported2.6Not Reported
Any Skin1.23.60.33
Source: U.S. Centers for Disease Control and Prevention, National Center for Health Statistics. (2025). Interactive summary health statistics for adults: Percentage of any type of cancer for adults aged 18 and over; United States, 2024; Percentage of breast cancer for adults aged 18 and over, United States, 2024; Percentage of cervical cancer for women aged 18 and over, United States, 2024. U.S. Department of Health and Human Services.

Top Cancer Sites

Cancer incidence among males, delay-adjusted and age-adjusted rate per 100,000 population, 2022
CancerAI/AN* MalesTotal Population MalesRatio (AI/AN* / Total)
All Sites468.8500.30.94
Colon & Rectum (Including Appendix)60.943.51.40
Esophagus7.87.31.07
Kidney34.423.61.46
Liver & Intrahepatic Bile Duct (IBD)20.213.91.45
Lung49.351.00.97
Oral Cavity & Pharynx19.617.91.09
Pancreas10.515.90.66
Prostate108.2133.60.81
Stomach12.49.61.29
Source: National Institues of Health, National Cancer Institute. (2025). SEER 5-year age-adjusted incidence rates, 2018-2022: All stages by cancer site and race/ethnicity, male, all ages. U.S. Department of Health and Human Services.
Cancer incidence among females, delay-adjusted and age-adjusted rate per 100,000 population, 2022
CancerAI/AN* FemalesTotal Population FemalesRatio (AI/AN* / Total)
All Sites482.4441.71.09
Breast136.4136.51.00
Cervical15.17.81.94
Colon & Rectum (Including Appendix)49.634.01.46
Kidney19.912.01.66
Liver & Intrahepatic Bile Duct (IBD)14.45.82.48
Lung48.443.71.11
Pancreas11.612.70.91
Stomach9.16.51.40
Uterus38.329.21.31
Source: National Institues of Health, National Cancer Institute. (2025). SEER 5-year age-adjusted incidence rates, 2018-2022: All stages by cancer site and race/ethnicity, female, all ages. U.S. Department of Health and Human Services.

Five-Year Survival Rates

5-year survival rate among males, percentage, 2015–2021
CancerAI/AN* MalesTotal Population Males Ratio (AI/AN* / Total)
All Sites57.168.70.83
Colon & Rectum (Including Appendix)60.764.50.94
Kidney77.478.80.98
Liver & IBD17.521.70.81
Lung17.423.80.73
Pancreas6.213.10.47
Prostate92.497.90.94
Stomach15.534.20.45
Source: National Institues of Health, National Cancer Institute. (2025). SEER 5-rear relative survival rates, 2015-2021: All stages by cancer site and race/ethnicity, male, all ages. U.S. Department of Health and Human Services.
5-year survival rate among females, percentage, 2015–2021
CancerAI/AN* FemalesTotal Population FemalesRatio (AI/AN* / Total)
All Sites65.771.20.92
Breast86.691.70.94
Cervical72.768.01.07
Colon & Rectum (Including Appendix)64.066.40.96
Kidney81.681.41.00
Liver & IBD20.722.80.91
Lung26.932.60.83
Pancreas8.213.50.61
Stomach21.143.20.49
Uterus84.081.11.04
Source: National Institues of Health, National Cancer Institute. (2025). SEER 5-year relative survival rates, 2015-2021: All stages by cancer site and race/ethnicity, female, all ages. U.S. Department of Health and Human Services.

Mortality

5-year mortality among males, age-adjusted rate per 100,000 population, 2019–2023
CancerAI/AN* MalesTotal Population MalesRatio (AI/AN* / Total)
All Sites180.5171.51.05
Colon & Rectum (Including Appendix)21.015.31.37
Liver & IBD15.79.41.67
Lung35.237.20.95
Pancreas10.912.90.84
Prostate18.919.20.98
Stomach6.83.51.94
Source: National Institues of Health, National Cancer Institute. (2025). U.S. 5-year age-adjusted mortality rates, 2019-2023: By cancer site and race/ethnicity, male, all ages. U.S. Department of Health and Human Services.
5-year mortality among females, age-adjusted rate per 100,000 population, 2019–2023
CancerAI/AN* FemalesTotal Population FemalesRatio (AI/AN* / Total)
All Sites141.2126.31.12
Breast17.719.20.92
Cervical3.02.21.36
Colon & Rectum (Including Appendix)14.810.81.37
Liver & IBD8.44.31.95
Pancreas10.19.91.02
Stomach3.82.01.90
Uterus4.95.30.92
Source: National Institues of Health, National Cancer Institute. (2025). U.S. 5-year age-adjusted mortality rates, 2019-2023: By cancer site and race/ethnicity, female, all ages. U.S. Department of Health and Human Services.

Health Care Use

Females ages 40 and over who had a mammogram within the past 2 years, crude percentage, 2019
AI/AN* FemalesTotal Population FemalesRatio (AI/AN* / Total)
61.379.80.77
Source: U.S. Centers for Disease Control and Prevention, National Center for Health Statistics. (2023). Health, United States 2020-2021 (Table CanBrTest). U.S. Department of Health and Human Services.
Females aged 21 to 65 years receiving a cervical cancer screening based on the most recent guidelines, percentage, 2021
AI/AN* FemalesTotal PopulationRatio (AI/AN* / Total)
53.873.90.73
Source: U.S. Centers for Disease Control and Prevention, National Center for Health Statistics. (2025). National Health Interview Survey, Healthy People 2030: Increase the proportion of females who get screened for cervical cancer in 2021. U.S. Department of Health and Human Services.
Adults aged 45 to 75 years receiving a colorectal cancer screening based on the most recent guidelines, percentage, 2023
AI/AN*Total PopulationRatio (AI/AN* / Total)
51.063.50.80
Source: U.S. Centers for Disease Control and Prevention, National Center for Health Statistics. (2025). National Health Interview Survey, Healthy People 2030: Adults receiving colorectal cancer screening based on the most recent guidelines, 2023. U.S. Department of Health and Human Services.

*Population is non-Hispanic in the data source.


Date Last Reviewed: January 2026